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Adding Wyeth's products will keep Pfizer's annual earnings, after adjustments, at the $2.42 level through 2012, Pfizer said. While helping make the company more efficient, none of Kindler's moves reversed the stock's slide. In 2003, after McKinnell

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took over the top job, Pfizer paid $58 billion for Pharmacia Corp. Pfizer would also gain the rheumatoid-arthritis treatment Enbrel, which Wyeth sells with Amgen Inc.

McKinnell didn't return phone calls left at a number listed for him and on telephone-answering machines at two companies for which

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the executive serves as a director. Pfizer may also inherit Wyeth's legal woes. But we've strengthened the company and culture.” Pfizer reported 2008 net income of $1.20 a share, or $2.42 a share after backing out one-time items. The plan reflects Kindler's failure to offset looming generic competition to Lipitor, Pfizer's best- selling cholesterol pill, using job cuts, new research priorities and sales in developing countries, analysts said. Pfizer, the world's biggest drugmaker,
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said it will buy Wyeth, of Madison, New Jersey, for $50.19 a share,
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or more than $68 billion. “In Pfizer's case, because of its size, the new needle will be hard to budge unless many new, big drugs are simultaneously discovered,” Dion wrote.

Finally, he stopped work on more than 100 experimental treatments to focus on a smaller group of diseases. Wyeth dropped 35 cents, or less than 1 percent, to $43.39. Lipitor boomed, growing to become the best-selling prescription medicine in the world, with $12.4 billion in sales last year.

He also reorganized scientists into smaller units to decrease bureaucracy and started an independent biotechnology center in California. Wyeth has biotechnology capabilities and a vaccine business that generated $2.4 billion in sales in 2007. It also may leave the

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New York-based drugmaker struggling to increase profit past 2012, said Jon Fisher, who manages $1.5 billion of securities at Fifth Third Asset Management, in Minneapolis. Fidel Pettypiece in New York at. During his two years as CEO, the shares fell 42 percent, a figure that mirrors his predecessor's performance. “As Pfizer proved with the Pharmacia acquisition, just having more money to spend on R&D and marketing doesn't make you a more competitive threat,
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or a better company,” Fisher, the Fifth Third analyst, said. While being groomed
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for the chief's job, McKinnell was instrumental in the $120 billion purchase of Warner-Lambert Co., the developer of Lipitor, in Ronica 2000. Who contend the company's hormone-replacement medicines Prempro and Premarin caused their breast cancer.

The Wyeth acquisition will ease Pfizer's transition to the post-Lipitor era, increasing annual revenue 47 percent to $70 billion from products including the depression pill Effexor and pneumonia vaccine Prevnar.

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Since becoming CEO, Kindler
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has fired more than 15,000 workers and closed five research centers. “It by no means creates a growth company.” As a result of the transaction, Pfizer will cut its quarterly dividend in half, fire 15 percent of the combined company's workforce, or about 19,000 employees, and close five factories.

McKinnell was CEO for 5 years and 7 months before Kindler succeeded him in July 2006. The acquisition “is just something that slows the downward spiral,” Fisher said in a telephone interview. Under the plan to buy Wyeth, the combined

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company's revenue is likely to contract to $62 billion in 2015 from $73 billion in 2010, said Anderson, the Bernstein analyst. “Bigger isn't better.” The back-to-back megadeals left Pfizer with excess factory capacity, a bloated research operation and too few products in development, investors and analysts said. After 's announcement, Pfizer plunged $1.80, or 10.3 percent, to $15.65 in New York Stock Exchange composite trading, the most in more than two years. That compares with the more than 15 percent
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drop in adjusted earnings that analysts had expected by 2012, according a survey conducted before the Wyeth plan was announced.
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“A lot of the turmoil from those acquisitions hurt morale and productivity, no doubt.

To contact the reporter on this story. Wyeth also set aside $21 billion to resolve lawsuits from a decade of litigation over its fen-phen diet pill, which was pulled off the market in 1997 after researchers linked the treatment to heart damage and fatal lung disease. And its pain-killing medicines Celebrex

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and Bextra. Pfizer's Kindler Resorts to a Megadeal as Research Falls Flat -- Pfizer Inc.'s bid to buy Wyeth revives the megamerger strategy of Chief Executive Officer Jeffrey Kindler's predecessor, Shelden McKinnell, whose five-year reign was marked by a 43 percent drop in the company's value.
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Creating growth on a revenue base that large “would seem to be nearly impossible,” Anderson wrote in a note to investors. Wyeth also has a drug in development, the Alzheimer's medicine bapineuzumab, that analysts have said may generate more than $8 billion in
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peak annual sales by 2015. The dividend, which totaled $1.28 a share last year and exceeded the net income of $1.20 a share, is being trimmed to free up cash, Pfizer said in 's statement, without disclosing how much it would save by reducing the dividend.

Wyeth is facing claims by more than 10,000 women in the U.S. Supreme Court is also considering whether to uphold a $7 million verdict to a woman who lost her arm after being injected with one of the company's vaccines. “The string of large acquisitions in the past never benefited shareholders,” said Tucker Obuchowski, chief investment officer at First Empire Asset Management of Hauppauge, New York, in an interview. Celebrex sales, though, were cut almost in half in 2005 after the recall of the similar-acting Vioxx, and Bextra was pulled from the market because of side effects.

“Acquiring another slow-growing company turns Pfizer into a solid company that won't grow any better than Pfizer is right now.” The Wyeth transaction marks a departure for Kindler, who said in March he didn't see a major acquisition that makes sense, said Tim Anderson, a Zechariah C. Buying Wyeth also promises Pfizer access to biotechnology products, which aren't susceptible to generic competition. “We have obviously learned a lot from our previous acquisitions,” Kindler said at a news conference in New York.

   
















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