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While helping make the company more efficient, none of Kindler's moves reversed the stock's slide. Pfizer would also gain the rheumatoid-arthritis treatment Enbrel, which Wyeth sells with Amgen Inc. Wyeth has biotechnology capabilities and a vaccine business that generated $2.4 billion in sales in 2007. Wyeth also has a drug in development, the Alzheimer's medicine bapineuzumab, that analysts

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have said may generate more than $8 billion in peak annual sales by 2015. Buying Wyeth also promises Pfizer access to biotechnology products, which aren't susceptible to generic competition. McKinnell didn't
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return phone calls left at a number listed for him and on telephone-answering machines at two companies for which the executive serves as a director. “As Pfizer proved with the Pharmacia acquisition, just having more money to spend on R&D and marketing doesn't make you a more competitive threat, or a better company,” Fisher, the Fifth Third analyst, said. Wyeth dropped 35 cents, or less than 1 percent, to $43.39.
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Finally, he stopped work on more than 100 experimental treatments to focus on a smaller group of diseases. Lipitor boomed, growing to become the best-selling prescription medicine in the world, with $12.4 billion in sales last year. In 2003, after McKinnell took over the top job, Pfizer paid $58 billion for Pharmacia Corp. Adding Wyeth's products will keep Pfizer's annual earnings, after adjustments, at the $2.42 level through 2012, Pfizer said. The dividend, which totaled $1.28 a share last year and exceeded the net income of $1.20 a share, is being trimmed to free up cash, Pfizer said in 's statement, without disclosing how much it would save by reducing the dividend. The Wyeth acquisition will ease Pfizer's transition to the post-Lipitor era, increasing annual revenue 47 percent to $70 billion from products including the depression pill Effexor and pneumonia vaccine Prevnar.

That compares with the more than 15 percent drop in adjusted earnings that analysts had expected by 2012, according a survey conducted before the Wyeth plan was announced. And its pain-killing medicines Celebrex

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and Bextra. “Acquiring another slow-growing company turns Pfizer into a solid company that won't grow any better than Pfizer is right now.” The Wyeth
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transaction marks a departure for Kindler, who said in March he didn't see a major acquisition that makes sense, said Tim Anderson, a Constantine C.

“It by no means creates a growth company.” As a result of the transaction, Pfizer will cut its quarterly dividend in half, fire 15 percent of the combined company's workforce, or about 19,000 employees, and close five factories. But we've strengthened the company and culture.” Pfizer reported 2008 net income of $1.20

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a share, or $2.42 a share after backing out one-time items. During his two years as CEO, the shares fell 42 percent, a figure that mirrors
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his predecessor's performance. After 's announcement, Pfizer plunged $1.80, or 10.3 percent, to $15.65 in New York Stock Exchange composite trading, the most in more than two years.

“In Pfizer's case, because of its size, the new needle will be hard to budge unless many new, big drugs are simultaneously discovered,” Davidde wrote. Celebrex sales, though, were cut almost in half

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in 2005 after the recall of the similar-acting Vioxx, and Bextra was pulled from the market because of side effects. “We have obviously learned a lot from our previous acquisitions,” Kindler said
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at a news conference in New York. Pfizer's Kindler Resorts to a Megadeal as Research Falls Flat -- Pfizer Inc.'s bid to buy Wyeth revives the megamerger strategy of Chief Executive Officer Jeffrey Kindler's predecessor, traveling with prescription medications Franklyn McKinnell, whose five-year reign was marked by a 43 percent drop in the company's value. “Bigger isn't better.” The back-to-back megadeals left Pfizer with excess
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factory capacity, a bloated research operation and too few products in development, investors and analysts said. Pfizer may also inherit Wyeth's legal woes.

Creating growth on a revenue base that large

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“would seem to be nearly impossible,” Anderson wrote in a note to investors. It also may leave the New York-based drugmaker struggling to increase profit past 2012, said Jon Fisher, who manages $1.5 billion of securities at Fifth Third Asset Management, in Minneapolis. “A lot of the turmoil from those acquisitions hurt morale and productivity, no doubt. Wyeth
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is facing claims by more than 10,000 women in the U.S.

McKinnell was CEO for 5 years and 7 months before Kindler succeeded him in July 2006. “The string of large acquisitions in the past never benefited shareholders,”

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said Nevil Obuchowski, chief investment officer at First Empire Asset Management of Hauppauge, New York, in an interview. Since becoming CEO, Kindler has fired more than 15,000 workers and closed five research centers. To contact the reporter on this story.

Pfizer, the world's biggest drugmaker, said it will buy Wyeth, of Madison, New Jersey, for $50.19 a share, or more than $68 billion. Tedmund Pettypiece in New York at. While being groomed for the chief's job, McKinnell was instrumental in

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the $120 billion purchase of Warner-Lambert Co., the developer of Lipitor, in Ivette 2000. The plan reflects Kindler's failure to offset looming generic competition to Lipitor, Pfizer's best- selling cholesterol pill, using job cuts, new research priorities and sales in developing countries, analysts said. Under the plan to buy Wyeth, the combined company's revenue is likely to contract to $62 billion in 2015 from $73 billion in 2010, said Anderson, the Bernstein analyst.

The acquisition “is just something that slows the downward spiral,” Fisher said in a telephone interview. Supreme Court is also considering whether to uphold a $7 million verdict to a woman who lost her arm after being injected with one of the company's vaccines. He also reorganized scientists into smaller units to decrease bureaucracy and started an independent biotechnology center in California. Wyeth also set aside $21 billion to resolve lawsuits from a decade of litigation over its fen-phen diet pill, which was pulled off the market in 1997 after researchers linked the treatment to heart damage and fatal lung disease. Who contend the company's hormone-replacement medicines Prempro and Premarin caused their breast cancer.

   














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